Figure 7.

Effect of LY2969822 on the rat paw incision model of tactile allodynia. After measurement of tactile threshold (baseline), a surgical incision was made in the hind paw of rats. After a 24 h recovery period, confirmation of tactile allodynia was established (<4 g) and rats were randomized to treatment groups (post‐incision). At 90 min after administration of vehicle (1% HEC), 3 or 10 mg·kg⁻¹ (active equivalent) of LY2969822 p.o. or 30 min after administration of 3 mg·kg⁻¹ morphine by the s.c. route, the degree of tactile allodynia was measured. Values are mean ± SEM, n = 7 per group. *Indicates significantly different versus vehicle response at the corresponding time point (P < 0.05, two‐way ANOVA followed by post hoc Dunnett's test).