Figure 1.
Effects of eucalyptol on CFA‐induced paw swelling in mice. (A) Schedule of treatment and experimental procedures. Paw oedema (% increase in paw volume) was measured by plethysmography directly (0 h), 2, 4, 24 and 48 h after injection of CFA (10 μL per paw) into the hind paw. Vehicle (corn oil), eucalyptol (30, 100 or 300 mg·kg−1) or ibuprofen (30 mg·kg−1) were injected (i.p.) 30 min before testing time points at 0, 24 and 48 h and in between at 6 and 30 h after CFA injection (total of five injections). (B) Percent increase in paw volume of CFA‐injected mice treated (i.p.) with eucalyptol (Euc) doses of 30, 100 or 300 mg·kg−1 or vehicle (Veh). The control group (Control) received saline injection into the hind paw instead of CFA and treatment with vehicle (corn oil) thereafter. n = 6–8 mice per group. # P < 0.05, significantly different from control group; *P < 0.05, significantly different from CFA + Veh group, one‐way ANOVA.