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. 2017 Apr 11;5:24. doi: 10.3389/fchem.2017.00024

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Copyright © 2017 Grassi, Maisetta, Maccari, Esin and Batoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activity of TB_L1FK and TB_KKG6A, used alone and in combination with EDTA, against preformed (24-h old) biofilms of S. aureus ATCC 33591 (A,B) and P. aeruginosa ATCC 27853 (C,D). The antibiofilm activity of the peptides, EDTA and the peptide-EDTA combinations was evaluated by CFU counting after 24 h of incubation. Control (CTRL) represents untreated biofilms. Data are reported as mean ± standard error of at least three independent experiments. ^*p < 0.05; ^**p < 0.01; ^***p < 0.001 (one way ANOVA followed by Tukey-Kramer post-hoc test).