Figure 3.

Nejire/CBP binding at different tolerance genes. A survey of basal CBP binding across the six alcohol tolerance genes was acquired from the modENCODE database (Celniker et al., 2009). Peak plots depict ChIP-seq signal obtained from immunoprecipitated chromatin from adult female flies using a CBP antibody superimposed on representative Refseq transcript isoforms for six known tolerance genes. All of these genes have been previously shown to be induced by both benzyl alcohol and ethanol (Ghezzi et al., 2013). Strong Nejire/CBP binding is localized near the transcription start sites or within the first exon of these genes. Vertical scale bars denote fold enrichment over input.