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. 2017 Apr 11;10:103. doi: 10.3389/fnmol.2017.00103

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Copyright © 2017 Ghezzi, Li, Lew, Wijesekera and Atkinson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A mutation in slo blocks CBP-induced alcohol resistance. (A) Schematic depiction of the 2-day treatment protocol. A HS inducible transgenic construct in which the Hsp70 promoter drives expression of a nejire cDNA was used to drive expression of CBP in a null slo mutant background. Induction of the transgene was performed 24 h prior to sedation with ethanol. (B) Ethanol recovery curves of slo^MI02233 (slo^−/−) flies carrying the hs-nej⁺ transgene. The black curve represents recovery from uninduced flies (Control), whereas the gray curve represents recovery from a CBP-induced flies (HS). (C) The average recovery time of control and heat-shocked induced flies (HS) is plotted. CBP induction does not affect recovery time from ethanol. Error bars represent SEM (Student’s t-test: not significant).