Figure 3. The deacetylase activity of HDAC6’s first domain is required for normal memory retention.

A. Schematic showing the functional domains of HDAC6. Critical active site residues for the deacetylase (DAC) domains are shown above and known targets of HDAC6 are shown below. Adapted from (Du et al., 2010), reviewed in (Boyault et al., 2007). B. Larval preference for AM vs OCT (1 = all prefer AM; −1 = all prefer OCT) after 20 minutes in wild-type and HDAC6 overexpression controls. (N = 10 – 12) (Box and whisker plots represent minimum, 1^st quartile, median, 3^rd quartile and maximum) C. Larval preference for AM vs OCT for HDAC6 overexpression in the HDAC6 reduced background after 20 minutes. (N= 12 – 16) C. Larval 20 minute learning Indexes calculated from the AM+ and OCT+ preferences shown in (B,C). Error bars represent +- s.e.m. 2-tailed Mann-Whitney U test was used for statistical analysis. * p < 0.05; ** p < 0.01