FIG. 8.

The time from maximal groove exposure to formation of the 6HB is briefer for ΔCT. C34 inhibits WT-induced fusion more effectively than ΔCT-induced fusion at the TAS, indicating that the grooves of ΔCT are less well exposed than those of the WT at this stage. Inhibition of fusion by C34 is the same for the WT and ΔCT at the LAS. Once grooves are fully exposed, ΔCT more quickly folds into a 6HB, illustrated as shorter transition arrows between the TAS and the LAS and between the LAS and fusion for ΔCT. The progression from left to right denotes a reaction coordinate (rather than time) for fusion.