FIG. 1.

Vector dose-response profiles in AAV1-, AAV2-, and AAV8-EF1α-nlslacZ-transduced mouse livers. The percentage of transduced hepatocytes in the livers (A), total β-galactosidase antigen levels (B), and number of double-stranded vector genomes per diploid genomic equivalent (ds-vg/dge) (C) are shown as a function of injected vector doses. Solid markers represent the values obtained from the present study. The dose-response profiles in AAV2-EF1α-nlslacZ-mediated liver transduction were obtained from our previous study (39) for comparison and are depicted with open circles. Values are means ± standard deviation.