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Reduction of SMAD4 expression is correlated with inflammatory stromal features. Representative immunohistochemical staining patterns of SMAD4 and the status of lymphocyte infiltration are shown according to the expression status. The sections were stained with hematoxylin and eosin (H&E) and anti‐SMAD4 polyclonal antibodies. Original magnification, ×100, scale bar = 50 μm.
