Table 1.
Correlation between malignant transformation and clinicopathological factors in 150 oral leukoplakia patients
| Characteristics | Total | Malignant transformation | P‐value | |
|---|---|---|---|---|
| Yes n (%) | No n (%) | |||
| 150 | 23 (15.3) | 127 (84.7) | ||
| Age (years) | ||||
| Median | 62.3 | 66 | 61.7 | |
| Range | 19–87 | 47–87 | 19–87 | |
| ≤65 | 85 | 12 (14.1) | 73 (85.9) | 0.637 |
| >65 | 65 | 11 (16.9) | 54 (83.1) | |
| Sex | ||||
| Male | 76 | 9 (11.8) | 67 (88.2) | 0.229 |
| Female | 74 | 14 (18.9) | 60 (81.1) | |
| Oral subsite | ||||
| Gingiva | 64 | 11 (17.2) | 53 (82.8) | 0.128 |
| Tongue | 52 | 11 (21.2) | 41 (78.8) | |
| Buccal mucosa | 21 | 1 (4.8) | 20 (95.2) | |
| Others | 13 | 0 (0) | 13 (100) | |
| Grade of dysplasia | ||||
| None | 101 | 13 (12.9) | 88 (87.1) | 0.427 |
| Mild | 37 | 7 (18.9) | 30 (81.1) | |
| Moderate, severe | 12 | 3 (25.0) | 9 (75.0) | |
| SMAD4 expression | ||||
| High | 84 | 6 (7.1) | 78 (92.9) | 0.0017a |
| Low | 66 | 17 (25.8) | 49 (74.2) | |
| Lymphocyte infiltration | ||||
| Low | 51 | 2 (3.9) | 49 (96.1) | 0.0054a |
| High | 99 | 21 (21.2) | 78 (78.8) | |
The chi‐square test was used to examine the correlation between malignant transformation and clinicopathological factors in 150 oral leukoplakia patients.
a
P < 0.01.