Table 3.
Correlation between SMAD4 expression and clinicopathological factors in 150 oral leukoplakia patients
| Characteristics | Total | SMAD4 expression | P‐value | |
|---|---|---|---|---|
| High n (%) | Low n (%) | |||
| 150 | 84 (56.0) | 66 (44.0) | ||
| Age (years) | ||||
| Median | 62.3 | 66 | 61.7 | |
| Range | 19–87 | 47–87 | 19–87 | |
| ≤65 | 85 | 49 (57.6) | 36 (42.4) | 0.642 |
| >65 | 65 | 35 (53.8) | 30 (46.2) | |
| Sex | ||||
| Male | 76 | 42 (11.7) | 34 (88.3) | 0.854 |
| Female | 74 | 42 (19.2) | 32 (80.8) | |
| Oral subsite | ||||
| Gingiva | 64 | 33 (51.6) | 31 (48.4) | 0.586 |
| Tongue | 52 | 25 (48.1) | 27 (51.9) | |
| Buccal mucosa | 21 | 14 (66.7) | 7 (33.3) | |
| Others | 13 | 12 (92.3) | 1 (0.08) | |
| Grade of dysplasia | ||||
| None | 101 | 55 (54.5) | 46 (45.5) | 0.859 |
| Mild | 37 | 22 (59.5) | 15 (40.5) | |
| Moderate, severe | 12 | 7 (58.3) | 5 (41.7) | |
| Lymphocyte infiltration | ||||
| Low | 51 | 39 (76.5) | 12 (23.5) | 0.00029** |
| High | 99 | 45 (45.5) | 54 (54.5) | |
The chi‐square test was used to examine the correlation between SMAD4 expression and clinicopathological factors in 150 OL patients.
a
P < 0.01.