Figure 6.
Antitumor effects of chLpMab‐2 on CHO/hPDPN tumor development. CHO/hPDPN cells (3 × 106 cells/100 μL) were subcutaneously inoculated into BALB/c nude mice. After 1 day, 100 μg of chLpMab‐2 or control human IgG was injected into the peritoneal cavity of the mice. The antibodies were injected once weekly for 4 weeks (control group: n = 6; chLpMab‐2 group: n = 6). The tumor diameter was measured every 3‐4 days and was calculated using the following formula: tumor volume = W2 × L/2, where W is the short diameter and L is the long diameter. (A) Comparison of the tumor size and tumor incidence in nude mice (day 21). (B) Comparison of the tumor size (day 21). (C) Primary tumor growth in human IgG and chLpMab‐2‐treated mice. **P < 0.01; ****P < 0.001 with two‐way ANOVA.