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. 2017 May;66(5):1001–1011. doi: 10.1016/j.jhep.2017.01.001

Fig. 1.

Fig. 1

ARC liver disease in Vps33bfl/fl-AlfpCre mice. (A) Plasma ALP activity, (B) plasma ALT activity (C) liver mass and (D) total plasma bile acid levels assessed in 14-week-old normal chow fed and cholic acid (CA) fed Vps33bfl/fl-AlfpCre and Vps33bfl/fl mice (n = 4–6). (E) Trichrome staining of liver sections from 14-week-old CA fed mice and 12-month-old mice fed with normal diet (n = 3). Graphs are presented with medians and IQR. p values (Mann Whitney U test): ALP activity, p = 0.0317 and p = 0.0022; ALT activity p = 0.0591 and p = 0.1775; plasma bile acids, p = 0.0043 and p = 0.0022; liver mass, p = 0.0117 and p = 0.0050 (normal chow fed and CA fed comparisons respectively).