Table 1.
Concentrations of bile acids in plasma from Vps33bfl/fl and Vps33bfl/fl-AlfpCre mice fed 0.5% cholic acid.
| Bile acid |
Vps33bfl/fl |
Vps33bfl/fl-AlfpCre |
Comparison | ||||
|---|---|---|---|---|---|---|---|
| Median, μM | 25th Percentile | 75th Percentile | Median, μM | 25th Percentile | 75th Percentile |
p value (Mann Whitney U) |
|
| TCA | 1.99 (9.69%) | 1.49 | 4.16 | 97.9 (54.55%) | 46.2 | 183 | 0.002 |
| GCA | 1.09 (5.31%) | 0.57 | 1.61 | 10.6 (5.91%) | 6.99 | 24.4 | 0.002 |
| CA | 3.44 (16.75%) | 2.19 | 5.84 | 24.2 (13.48%) | 5.50 | 33.0 | 0.02 |
| Tauro-diOH-C | 1.98 (9.64%) | 1.28 | 2.62 | 14.8 (8.25%) | 5.67 | 25.4 | 0.004 |
| Glyco-diOH-C | 0.08 (0.39%) | 0.038 | 0.15 | 0.74 (0.41%) | 0.20 | 2.30 | 0.002 |
| DiOH-C | 11.8 (57.45%) | 5.41 | 19.9 | 24.0 (13.37%) | 11.8 | 33.4 | 0.13 (ns) |
| Tauro-tetraOH-C | 0.08 (0.39%) | 0.068 | 0.16 | 6.40 (3.57%) | 1.77 | 10.8 | 0.0048 |
| Glyco-tetraOH-C | 0.03 (0.15%) | 0.018 | 0.057 | 0.78 (0.43%) | 0.64 | 2.68 | 0.0238 |
| TetraOH-C | 0.05 (0.23%) | 0.03 | 0.058 | 0.06 (0.03%) | 0.03 | 0.09 | 0.5097 (n.s.) |
Contributions of individual bile acids to the total bile acid pool are listed as percentages in parenthesis.
CA, cholic acid; C, cholanoate; T, tauro; G, glyco; DiOH, dihydroxy; tetra-OH, tetrahydroxy.