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. 2017 Apr 11;36:50. doi: 10.1186/s13046-017-0526-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Diagram of the putative effects of itraconazole on gastric cancer cells. Itraconazole down-regulates the expression of Gli1 by yet unknown mechanisms and subsequently regulates the expression of several downstream target genes, including p21^waf1/cip1, and p27^kip1, Bax and PARP, thereby regulating many cellular processes, such as proliferation, survival, cell cycle and apoptosis