Table 2.

Interventions according to groups

Group	Type	Intranasal	Oral
A	Experimental	Ketamine (4.0 mg/kg, maximum 100 mg)a + midazolam (0.2 mg/kg, maximum 5.0 mg)b	Placebo
B	Drug route comparison	Placebo	Ketamine (4.0 mg/kg, maximum 100 mg)a + midazolam (0.5 mg/kg, maximum 20 mg)c
C	Control	Placebo	Midazolam (1.0 mg/kg, maximum 20 mg)c

^aInjectable solution in a concentration of 50.0 mg/mL (Ketamin S, Cristalia, Sao Paulo, Brazil

^bInjectable solution in a concentration of 5.0 mg/mL (Dormire solução injetável, Cristalia, Sao Paulo, Brazil)

^cOral solution in a concentration of 2.0 mg/mL (Dormire solução oral, Cristalia, Sao Paulo, Brazil)