Table 2.
Comparison to other studies
| SBUH, 62 cases review | UAlbany 139 cases review | SBUH 34 cases review | |
|---|---|---|---|
| Methods | Chart review of patients with positive smears from 2008 to 2014 | Hospital records of babesiosis in NYS for 11 years (1982–1993) | Records of SBUH and VAa hospitalized patients for 13 years with positive blood smears |
| Classified to have mild or severe (death, >2 weeks in hospital, ICU admission) | Controls with FUOb, negative blood smears, matched by age and sex | ||
| Transferred from other hospital | 27 (44%) | NA | 30 (88%) |
| Median age (years) | 64 | 66 | 46 |
| Mean hospital stay (days) | 9.6 | 11.7 | 12.7 |
| ICU admission | 20 (38%) | 35 (25.2%) | – |
| Splenectomy | 9 (15%) | 16 (11.5%) | 11 (32%) |
| Mean hemoglobin (g/dL) | 10.6 | 11.3 | 10 |
| Mean platelets (×103/μL) | 86 | 102 | 92 |
| Mean LDH (U/L) | 742 | 572 | – |
| Mean ALT (U/L) | 66 | – | 99 |
| Mean AST (U/L) | 85 | – | 121 |
| Mean parasitemia (%) | 3.4% | – | 7.4% |
| Mean peak parasitemia (%) | 4.4% | – | 7.6% |
| Max parasitemia | 25% | – | 30% |
| Mean days of parasitemia | 6 | – | 8.5 |
| Treatment | Clindamycin 15 (24%) Quinine 13 (21%) Azithromycin 59 (95%) Atovaquone 59 (95%) |
Clindamycin 110 (79%) Quinine 106 (76%) |
Clindamycin 33 (97.1%) Quinine 28 (82.3%) Azithromycin 2 (5.9%) Atovaquone 15 (44%) |
| Exchange transfusions | 12 (19%) | 6 (4.3%) | 7 (20.6%) |
| Died | 1 (2%) | 9 (6.5%) | 3 (8.8%) |
| Associations | High-grade parasitemia and: Malignancy Splenectomy LDH AST Total bilirubin |
Severe disease and: Cardiac disease/murmur Splenectomy Alkaline phosphatase WBC Higher parasitemia |
Complicated babesiosis and: Hemoglobin <10 g/dL Higher parasitemia |
For the purpose of a comparison, all patients from SBUH with positive blood smear were included in this table regardless of antimicrobials that were used for babesiosis therapy (n = 62)
aVA–Veteran Affairs Hospital
bFUO–Fever of Unknown Origin