Table 3.
Patients treated with clindamycin and quinine in addition to azithromycin and atovaquone
| Patient | Initial therapy | Changes | Admitted to ICU | ID involved |
|---|---|---|---|---|
| 1 | Azithromycin/atovaquone | Changed to clindamycin/quinine on day #5 due to poor clinical response | Yes | Yes |
| 2 | Azithromycin/atovaquone | Changed to clindamycin/quinine on day #2 due to high % parasitemia on admission → changed back to azithromycin/atovaquone on day #4 due to QT prolongation | Yes | Yes |
| 3 | Azithromycin/atovaquone | Initial therapy at outside hospital; started on clindamycin/quinine on admission to SBUH | No | No |
| 4 | Clindamycin/quinine | Changed to azithromycin/atovaquone on day #2 per ID recommendations | Yes | Yes |
| 5 | Azithromycin/atovaquone | Initial therapy started at the outside hospital → patient developed respiratory failure, intubated, changed to clindamycin/quinine, and transferred to SBUH | Yes | No |
| 6 | Clindamycin/quinine | Initial therapy was changed to azithromycin/atovaquone on day #1 per ID recommendations | Yes | Yes |
| 7 | Clindamycin/quinine | ID recommended to change regimen to azithromycin/atovaquone on day #2, however antibiotics were changed to azithromycin/clindamycin per primary team due to lack of IV formulation of atovaquone → therapy changed to azithromycin/atovaquone on day #7 | Yes | Yes |
| 8 | Clindamycin/quinine | Therapy changed to azithromycin/atovaquone on day #6 | No | No |
| 9 | Clindamycin/quinine | Therapy changed to azithromycin/atovaquone on day #3 | No | Yes |
| 10 | Clindamycin/quinine/azithromycin | Azithromycin discontinued on day #5 → changed to azithromycin/atovaquone on day #17 due to hypoglycemia. Patient with prolonged parasitemia | Yes | Yes |
| 11 | Clindamycin/Quinine/Atovaquone | Atovaquone discontinued on day #2 → regimen changed to azithromycin/atovaquone on day #3 | Yes | Yes |
ID infectious diseases