Table 1.
Morphometric data and plasma values of rats in absence or presence of metformin or sulodexide
| Control N = 5 |
HFD N = 8 |
Metformin N = 8 |
Sulodexide N = 7 |
|
|---|---|---|---|---|
| Body composition | ||||
| Body weight (g) | 389.6 ± 12.9 | 528.3 ± 11.6* | 532.5 ± 16.2* | 555.1 ± 188* |
| Heart weight (g) | 1.00 ± 0.09 | 1.29 ± 0.05* | 1.39 ± 0.08* | 1.33 ± 0.04* |
| Heart weight/body weight (×1000) | 2.55 ± 0.15 | 2.44 ± 0.09 | 2.61 ± 0.13 | 2.40 ± 0.06 |
| Perirenal fat (g) | 3.44 ± 0.40 | 14.15 ± 1.57* | 15.90 ± 1.52* | 16.21 ± 1.27* |
| Epididymal fat (g) | 3.88 ± 0.41 | 10.19 ± 1.23* | 10.85 ± 0.84* | 13.00 ± 1.62* |
| Blood/plasma characteristics | ||||
| Haematocrit (%) | 50.5 ± 0.5 | 50.5 ± 1.5 | 51.3 ± 0.5 | 48.3 ± 0.4 |
| Total cholesterol (mmol/l) | 2.14 ± 0.22 | 2.86 ± 0.14* | 2.58 ± 0.21 | 2.79 ± 0.05* |
| Triglycerides (mmol/l) | 0.76 ± 0.09 | 0.97 ± 0.18 | 0.71 ± 0.11 | 0.96 ± 0.21 |
| Fasted blood glucose (mmol/l)a | 6.66 ± 0.37 | 7.48 ± 0.57 | 7.42 ± 0.50 | 7.00 ± 0.60 |
| Fasted insulin (ng/ml)a | 0.16 ± 0.01 | 0.76 ± 0.13* | 0.59 ± 0.10* | 0.30 ± 0.06# |
Data are expressed as mean ± SEM
HFD high fat diet
* p < 0.05 vs. control group, # p < 0.05 vs. HFD group
aSeparate series of experiments (control n = 9, HFD n = 9, metformin n = 9, sulodexide n = 6)