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Primary breast cancer tissue immunostaining of patients with leptomeningeal metastasis. Breast cancer cells are syndecan-1 (CD138) (a1 and a2) and MUC-1 (CD227) (b1 and b2) strongly positive (intense brown staining of both in situ and infiltrating tumor cells). Non-neoplastic breast epithelium (arrow) shows glandular architecture with weak staining for both syndecan-1 and MUC-1 antibodies
