TABLE 1.
Sites of proviral insertion identified in MoFe2-induced lymphomas in NIH/Swiss mice
| Locus (chromosome) | Full gene name | CIS in MoFe2-induced tumorsa | Previously identified insertion siteb | Modelsc
|
|
|---|---|---|---|---|---|
| Mouse strain (virus) (reference) | Tumor type | ||||
| MF8T (2:E5) | Ras guanyl releasing protein 1 | Y | Y (CIS) | BXH2 (Akv) (44) | Myeloid |
| EμMyc (M-MuLV) (33) | B cell, T cell | ||||
| p27Kip−/+ (M-MuLV) (20) | B cell, T cell | ||||
| p27Kip−/− (M-MuLV) (20) | T cell | ||||
| AKXD (Akv) (44) | B cell, T/B mix | ||||
| NIH/Swiss (SL3-3) (22) | T cell | ||||
| EμMyc;Pim1(−);Pim2(−)(M-MuLV)(33) | B cell, T cell | ||||
| 3-19 (11:B3) | P101 regulatory subunit of PI3Kγ | Y | N | ||
| Jundm2 (12:D1) | Jun dimerization protein 2 (predicted) | Y | Y (CIS) | p27Kip−/+ (M-MuLV) (20) | T cell |
| p27Kip−/− (M-MuLV) (20) | T cell | ||||
| EμMyc (M-MuLV) (33) | B cell | ||||
| NMRI (SL3-3) (42) | T cell | ||||
| Cas-Br-M (Cas-Br-M MuLV) (21) | Myeloid | ||||
| Ahi1 (10:A3) | Abelson helper integration site | Y | Y (CIS) | SIM.S, NIH/Swiss (A-MuLV) (37) | B cell |
| Cdkn2a−/− (M-MuLV) (29) | B cell | ||||
| p27Kip−/+ (M-MuLV) (20) | T cell | ||||
| p27Kip−/− (M-MuLV) (20) | T cell | ||||
| NIH/Swiss (SL3-3) (22) | T cell | ||||
| AKXD (Akv) (44) | B cell | ||||
| Cbfb-MYH11 (MLV-Ampho4070A) (6) | Myeloid | ||||
| EμMyc; Pim1(−);Pim2(−)(M-MuLV) (33) | B cell, T cell, T/B mix | ||||
| EμMyc (M-MuLV) (33) | B cell | ||||
| BXH2 (Akv) (44) | Myeloid | ||||
| Rras2 (7:E3) | Ras-related protein 2 | Y | Y (CIS) | Cdkn2a−/− (M-MuLV) (29) | Lymphoma (unspecified) |
| p27Kip−/+ (M-MuLV) (20) | T cell | ||||
| p27Kip−/− (M-MuLV) (20) | T cell | ||||
| NIH/Swiss (SL3-3) (22) | T cell | ||||
| AKXD (Akv) (44) | B cell, T/B mix | ||||
| AKXD (17) | Myeloid, T cell | ||||
| EμMyc; Pim1(−); Pim2(−) (M-MuLV) (33) | B cell, T cell | ||||
| Rw1 (1:B) | RW1 protein (predicted) | Y | N | − | − |
| Rin2 (2:G1) | Ras and Rab interactor 2 | N | Y (CIS) | BXH2 (Akv) (44) | Unspecified |
| Irs2 (8:A1.1) | Similar to insulin receptor substrate 2 (predicted) | N | Y (CIS) | EμMyc; Pim1(−); Pim2(−) (M-MuLV) (33) | B cell |
| AKXD (Akv) (44) | B cell, T/B mix | ||||
| Traip (9:F1) | TRAF-interacting protein | N | N | − | − |
| Grf2 (2:A3) | Guanine nucleotide releasing factor 2 | N | N | − | − |
| Lamr1 (9:F3) | C laminin receptor | N | N | − | − |
| Kpnb1 (11:D) | Karyopherin (importin) beta 1 | N | N | − | − |
a
To determine whether a proviral integration site was a CIS in MoFe2-induced lymphomas, Southern blot analysis of multiple tumors was performed by using a region of each integration site as a probe. Y, yes; N, no.
b
To determine whether a proviral integration site in MoFe2-induced lymphomas had been previously reported, integration sites were compared to the RTCGD. Y, yes; N, no. Previously identified CISs are indicated in parentheses.
c
When proviral integration sites were previously identified on the RTCGD, the strain of mouse, virus infection, and tumor type from each study are indicated. T/B mix, mix of T and B cells.