Table 1.
Comparison between paclitaxel, ifosfamide, carboplatin, and etoposide regimen and Einhorn regimen
| TI-CE regimen | Einhorn regimen | |
|---|---|---|
| Conventional chemotherapy TI = 2 cycles Einhorn cytoreduction 1–2 cycles |
Paclitaxel (T) Ifosfamide (I) |
Ifosfamide Cisplatin Vinblastine |
| Number of high-dose cycles with stem cell rescue | 3 | 2 |
| Etoposide dose | 400 mg/m2 (D 1–3) | 750 mg/m2 (D 1–3) |
| Carboplatin dose | AUC = 8 (D 1–3) | 700 mg/m2 (D 1–3) |
Einhorn regimen uses carboplatin 700 mg/m2 body-surface area instead of AUC = 8 and etoposide 750 mg/m2, which is higher than the dose in TIGER regimen (etoposide 400 mg/m2). In TI-CE approach, carboplatin and etoposide high-dose therapy is given in three cycles every 21 days, whereas in Einhorn regimen, it is given in two cycles
AUC area under the concentration-time curve, D days, TI paclitaxel and ifosfamide, TI-CE paclitaxel + ifosfamide and carboplatin + etoposide