Table 3.
FISH analysis in CD34+ cell populations of nine patients
| FISH results | NGS results | |||||||
|---|---|---|---|---|---|---|---|---|
| Patient ID | IGHV mutation status | Cytogenetic alteration | Altered CD19+ cells (%) | Presence in CD34+ cells | Altered CD34+ cells (%) | Mutated gene | Mutational load CD19+ (%) | Mutational load CD34+ (%) |
| 2 | Unmutated | IGH alt | 80 | No | – | NOTCH1 | 51 | 31 |
| 15 | Mutated | 13q- | 65 | Yes | 25 | – | ||
| 16 | Unmutated | +12 | 22 | No | – | – | ||
| 17 | Mutated | IGH alt | 54 | No | – | – | ||
| 21 | Unmutated | 11q- | 64 | Yes | 49 | XPO1 | 39.5 | 31 |
| 21 | 13q- | 93 | Yes | 72 | ||||
| 23 | Unmutated | 11q- | 79 | Yes | 36 | – | ||
| 26 | Mutated | 13q- | 67 | Yes | 46.5 | – | ||
| 27 | Mutated | 13q- | 86 | No | – | – | ||
| 29 | Mutated | 13q- | 25 | No | – | – | ||