Table 1.
Crude and adjusted fecundability odds ratios (FOR)a for the association between perfluoroalkyl substances (ng/ml) and time to pregnancy among 451 primiparous women from a case-base study among the Norwegian Mother and Child Cohort (MoBa) Study, 2003–2004
| n (%) >LOQb |
nc | Median A (IQR)d | Median B (IQR)e | Crude | Adjustede | |||||
|---|---|---|---|---|---|---|---|---|---|---|
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| FOR | Lower Limit |
Upper Limit |
FOR | Lower Limit |
Upper Limit |
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| Perfluorinated Sulfonamide | ||||||||||
| PFOSA | 66 (14.6) | 226 | 0.04 (0.03, 0.04) | 0.03 (0.02, 0.07) | 0.95 | 0.75 | 1.22 | 0.91 | 0.71 | 1.17 |
| Perfluorinated Carboxylates | ||||||||||
| PFBA | 0 (0.0) | – | – | – | — | — | — | — | — | — |
| PFHpA | 63 (14.0) | – | – | – | — | — | — | — | — | — |
| PFOA | 451 (100.0) | 451 | 2.82 (2.21, 3.54) | 2.82 (2.21, 3.54) | 1.06 | 0.92 | 1.22 | 1.04 | 0.90 | 1.20 |
| PFNA | 451 (100.0) | 451 | 0.43 (0.32, 0.57) | 0.43 (0.32, 0.57) | 1.12 | 0.96 | 1.31 | 1.08 | 0.92 | 1.27 |
| PFDA | 336 (74.5) | 429 | 0.11 (0.05, 0.16) | 0.11 (0.06, 0.17) | 1.04 | 0.89 | 1.22 | 1.00 | 0.85 | 1.18 |
| PFUnDA | 421 (93.3) | 447 | 0.23 (0.14, 0.34) | 0.23 (0.14, 0.34) | 1.01 | 0.85 | 1.19 | 0.93 | 0.78 | 1.11 |
| PFDoDA | 114 (25.3) | 410 | 0.04 (0.03, 0.05) | 0.04 (0.02, 0.06) | 0.96 | 0.84 | 1.09 | 0.91 | 0.77 | 1.08 |
| PFTrDA | 122 (27.0) | 353 | 0.04 (0.03, 0.06) | 0.04 (0.02, 0.07) | 1.05 | 0.89 | 1.24 | 1.00 | 0.85 | 1.19 |
| PFTeDA | 4 (0.01) | – | – | – | — | — | — | — | — | — |
| Perfluorinated Sulfonates | ||||||||||
| PFHxS | 450 (99.8) | 451 | 0.70 (0.53, 1.06) | 0.70 (0.53, 1.06) | 0.98 | 0.91 | 1.06 | 0.97 | 0.90 | 1.05 |
| PFHpS | 412 (91.4) | 446 | 0.15 (0.10, 0.22) | 0.16 (0.10, 0.22) | 1.03 | 0.88 | 1.20 | 1.02 | 0.87 | 1.19 |
| PFOS | 451 (100.0) | 451 | 14.56 (11.70, 18.45) | 14.56 (11.70, 18.45) | 1.01 | 0.89 | 1.14 | 1.00 | 0.88 | 1.13 |
PFOSA: perfluorooctane sulfonamide; PFBA: perfluorobutanoic acid; PFHpA: Perfluoroheptanoic acide; PFOA: perlurooctanoic acid; PFNA: perfluorononanoic acid; PFDA: perfluorodecanoic acid; PFUNDA: perfluoroundecanoic acid; PFDoDA: perfluordodecanoic acid; PFTrDA: perfluorotridecanoic acid; PFTeDA: perfluorotridecanoic acid; PFHxS: perfluorohexane sulfonate; PFHpS: perfluoroheptane sulfonate; PFOS: perfluorooctane sulfonate
FORs represent the odds of conception in a given month per interquartile increase in PFAS (ng/ml) concentration, based on the interquartile distance corresponding to Median B.
The LOQ for PFBA was 0.1 ng/ml; the LOQ for all other compounds was 0.05 ng/ml.
Indicates the number of observations included in the FOR analysis (i.e., this is the number of women with PFAS concentration >LOQ plus women with measured PFAS concentration <LOQ). We did not analyze PFBA, PFHpA, or PFTeDA for lack of observations.
Medians were calculated among all 451 women, assigning a value equal to the LOQ/sqrt(2) for non-measured PFAS concentrations
Medians were calculated among women included in the FOR analysis (i.e., women with PFAS concentration >LOQ plus women with measured PFAS concentration <LOQ).
Adjusted for maternal age at conception and pre-pregnancy BMI