Table 1. Differential cell counts (prophylactic model and treatment model).
| Allergen-induced asthma models | Differential BALF counts (cell numbers ± SEM) | |||
|---|---|---|---|---|
| Eosinophils | Neutrophils | Macrophages | Lymphocytes | |
| Prophylactic model | ||||
| Allergen – HDM | ||||
| Saline control | 329 ± 170 | 763 ± 283 | 60,725 ± 13,721 | 21,550 ± 4,800 |
| Vehicle + HDM | 301,750 ± 22,605* | 227,583 ± 16,484* | 242,250 ± 20,579* | 131,450 ± 20,437* |
| CQ + HDM | 151,909 ± 17,391# | 153,655 ± 17,520# | 168,227 ± 18,120# | 101,936 ± 13,797# |
| Q + HDM | 121,778 ± 6,984# | 123,133 ± 12,419# | 150,778 ± 17,505# | 88,689 ± 15,446# |
| Allergen - Ovalbumin | ||||
| Saline control | 129 ± 129 | 2,137 ± 966 | 164,888 ± 63,857 | 71,250 ± 25,706 |
| Vehicle + OVA | 228,700 ± 40,250* | 217,900 ± 17,124* | 258,200 ± 34,905 | 117,590 ± 12,947 |
| CQ + OVA | 114,430 ± 6,335# | 113,030 ± 6,824# | 208,080 ± 37,431 | 67,120 ± 8,401 |
| Q + OVA | 134,900 ± 21,007# | 147,330 ± 20,739# | 171,660 ± 29,377 | 98,680 ± 19,500 |
| Treatment model | ||||
| Allergen - HDM | ||||
| Saline control | 353 ± 234 | 1079 ± 397 | 95,911 ± 9,907 | 39,700 ± 3,994 |
| Vehicle + HDM | 222,625 ± 18,383* | 274,500 ± 36,029* | 302,250 ± 29,842* | 149,438 ± 17,656* |
| CQ + HDM | 147,300 ± 10,964# | 177,000 ± 14,052# | 240,875 ± 20,747 | 130,750 ± 17,465 |
| Q + HDM | 149,000 ± 19,431# | 149,375 ± 15,427# | 203,750 ± 17,783# | 154,683 ± 27,903 |
Data shown above represents the mean of 8–11 animals in each group; *p < 0.05 (Saline vs HDM or OVA), #p < 0.05 (HDM or OVA vs CQ or Q) using 1-way ANOVA. CQ: chloroquine; Q: quinine; OVA: Ovalbumin; HDM: house dust mite; BALF: bronchoalveolar lavage fluid; SEM: standard error of means.