Table 2. BALF Cytokines and chemokines release in prophylactic models.
| Cytokines/Chemokines (pg/ml ± SEM) | Treatment groups | |||||||
|---|---|---|---|---|---|---|---|---|
| Allergen - HDM | Allergen – OVA | |||||||
| Saline control | Vehicle + HDM | CQ + HDM | Q + HDM | Saline control | Vehicle + HDM | CQ + HDM | Q + HDM | |
| IL-4 | 0.16 ± 0.04 | 14.68 ± 3.70* | 7.15 ± 0.90# | 6.47 ± 1.27# | 0.21 ± 0.06 | 12.02 ± 1.92* | 4.97 ± 0.65# | 6.76 ± 1.69# |
| IL-5 | 0.47 ± 0.07 | 34.22 ± 7.06* | 15.97 ± 3.92# | 18.64 ± 4.61# | 0.53 ± 0.09 | 52.65 ± 6.44* | 25.96 ± 6.64# | 19.41 ± 5.67# |
| IL-9 | 11.64 ± 4.25 | 37.56 ± 7.53* | 30.25 ± 6.48 | 17.50 ± 6.36# | 2.28 ± 0.42 | 13.08 ± 9.44 | 10.33 ± 7.80 | 28.72 ± 11.73 |
| IL-13 | 0.11 ± 0.06 | 19.67 ± 3.35* | 7.83 ± 2.50# | 4.40 ± 1.34# | 0.12 ± 0.08 | 14.32 ± 1.48* | 3.25 ± 0.85# | 6.12 ± 2.56# |
| IL-17 | 0.15 ± 0.05 | 1.26 ± 0.25* | 0.82 ± 0.22 | 0.84 ± 0.21 | 0.11 ± 0.05 | 1.16 ± 0.16* | 0.50 ± 0.14# | 0.65 ± 0.17# |
| IL-10 | 0.48 ± 0.14 | 66.44 ± 26.52* | 21.15 ± 7.81 | 2.64 ± 0.54# | n.d. | |||
| Eotaxin | 10.54 ± 2.01 | 98.19 ± 14.78* | 62.45 ± 7.89# | 39.20 ± 9.41# | 13.82 ± 5.31 | 147.30 ± 43.11* | 53.29 ± 11.17# | 54.65 ± 10.43# |
| KC | 19.5 ± 1.91 | 483.80 ± 114.20* | 219.90 ± 56.88# | 196.70 ± 63.07# | 36.77 ± 3.79 | 766.00 ± 50.93* | 480.30 ± 81.20# | 501.00 ± 52.83# |
| TNF-α | 1.24 ± 0.43 | 18.90 ± 3.41* | 10.90 ± 2.09# | 6.72 ± 1.36# | 0.81 ± 0.35 | 6.61 ± 1.18* | 4.14 ± 0.77 | 4.98 ± 0.67 |
| IP-10 | 3.48 ± 0.40 | 26.32 ± 4.80* | 18.58 ± 2.42 | 15.63 ± 2.50# | 4.48 ± 1.07 | 20.02 ± 3.36* | 14.44 ± 2.04 | 14.16 ± 1.61 |
| RANTES | 0.14 ± 0.12 | 8.67 ± 2.30* | 3.40 ± 0.80# | 2.12 ± 0.42# | 0.31 ± 0.20 | 2.99 ± 0.83* | 1.23 ± 0.39 | 1.86 ± 0.26 |
Data shown above represents the mean of 8–11 animals in each group; *p<0.05 (Saline vs HDM or OVA), #p < 0.05 (HDM or OVA vs CQ or Q) using 1-way ANOVA. CQ: chloroquine; Q: quinine; OVA: Ovalbumin; HDM: house dust mite extract; SEM: standard error of means; KC: keratinocyte chemoattractant; IP-10: interferon-γ-induced protein 10; RANTES: regulated on activation, normal T cell expressed and secreted; n.d.: not detected.