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Obesity phenotype of RS1−/− mice. (a) Appearance of wild-type and RS1−/− mice. A typical 5-month-old female C57BL/6J wild-type mouse (23.7 g) and a typical 5-month-old female RS1−/− mouse of the ninth generation of backcrossing with C57BL/6J (30.3 g) are shown. (b) Low-magnification electron micrographs of abdominal fat tissue from 5-month-old female RS1+/+ and RS1−/− mice from the same litter. Bar, 20 μm.
