Figure 9.
Pathway for interconversion between Nia-L and Nia-SI, demonstrated by photolysis measurements. (A) Scheme showing Nia-SI formation from Nia-L, only in the presence of an oxidized proximal cluster. (B) Photolysis spectra of the [NiFe] hydrogenase from D. vulgaris MF under a H2 atmosphere show “normal” formation of Nia-L. (C) Photolysis spectra of [NiFe] hydrogenase from D. vulgaris MF recorded under a N2 atmosphere show formation of both Nia-L and Nia-SI, under conditions where the proximal cluster is at least partially oxidized. Panels (B) and (C) adapted with permission from ref (60). Copyright 2014 Wiley-VCH.