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The effect of exercise-induced stress on wild-type (WT) and Wisp3−/− mice. Sagittal sections stained with toluidine blue of knee joints from WT and Wisp3−/− running wheel mice reveal similar changes, including hyperplastic synovium (dashed arrow), chondrification of noncartilagenous tissues (arrow), and loss of cartilage surface (arrowheads). F, femoral condyle; T, tibial plateau; M, meniscus; S, synovium.
