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Spatial distribution of APPV717I-CT100 and tauV337M transgene mRNA. Sagittal brain sections (each, 12 μm) from wild-type (WT), APPV717I-CT100 (CT100), tauV337M (Tau), and tauV337M× APPV717I-CT100 (COM) mice were analyzed by in situ hybridization with radiolabeled probes specific to human APP-CT100 (A), mouse APP (B), human tau (C), and mouse tau (D) mRNA. The data are representative of four independent samples per group.
