Figure 2.

Bar plots demonstrating distribution of parametric response mapping (PRM) of functional small airways disease (PRM^fSAD) and PRM of parenchymal disease (PRM^PD) in lung transplant recipients with irreversible spirometric decline by decline group status and respective control subjects. (A) Patients presenting with isolated decline in FEV₁ (FEV₁ First group) had significantly more PRM^fSAD compared with their matched control subjects (28 ± 3% vs. 15 ± 3%; P = 0.005). No significant difference was noted in PRM^PD values (n = 15 per group). (B) Patients presenting with simultaneous decline in both FEV₁ and FVC (Concurrent group) had significantly higher PRM^PD compared with their matched control subjects (39 ± 6% vs. 20 ± 2%; P = 0.02). No significant difference was noted in PRM^fSAD values between Concurrent patients and their matched control subjects (n = 7 per group). *P < 0.05. Data are presented as mean ± SEM.