Figure 7.

Survival stratified by spirometric decline pattern and parametric response mapping (PRM) of functional small airways disease (PRM^fSAD). FEV₁ First patients (presenting with isolated decline in FEV₁) with PRM^fSAD greater than or equal to 30% have an average survival similar to Concurrent patients (presenting with simultaneous decline in both FEV₁ and FVC) (2.5 ± 0.6 vs. 1.8 ± 0.6 yr; average difference, 0.67 yr; P = 0.42). FEV₁ First patients with PRM^fSAD less than 30% on average live longer than both Concurrent patients (P = 0.0005) and FEV₁ First patients with PRM^fSAD greater than or equal to 30% (P = 0.004). Open circles are censoring events (at the last patient visit).