Table 1.
Patient Characteristics at Baseline and Clinical Outcomes
| Characteristic | All (n = 199) | Baseline HRCT (n = 156) | Sequential HRCT (n = 105) |
|---|---|---|---|
| Age, yr, mean (SD) | 67.0 (8.4) | 67.5 (8.3) | 67.2 (8.7) |
| Male sex, n (%) | 153 (76.9) | 114 (73.1) | 73 (69.5) |
| White race, n (%) | 191 (96.0) | 150 (96.2) | 101 (96.2) |
| Never smoker, n (%) | 53 (26.8) | 46 (29.5) | 30 (28.9) |
| Time since diagnosis, yr, mean (SD) | 1.01 (1.1) | 1.1 (1.1) | 1.1 (1.1) |
| GAP stage, n (%) | |||
| 1 | 85 (43.2) | 66 (42.3) | 51 (48.6) |
| 2 | 86 (43.7) | 70 (44.9) | 46 (43.8) |
| 3 | 26 (13.2) | 20 (12.8) | 8 (7.2) |
| Coexisting illnesses, n (%) | |||
| CAD | 41 (20.6) | 30 (19.2) | 22 (21.0) |
| Diabetes | 26 (13.1) | 21 (13.5) | 17 (16.2) |
| GERD | 128 (64.3) | 106 (68.0) | 71 (67.2) |
| Lung function, mean (SD) | |||
| FVC % predicted | 73.0 (15.5) | 73.5 (15.6) | 75.0 (15.1) |
| DlCO % predicted | 46.1 (11.5) | 45.7 (12.3) | 47.1 (11.8) |
| Room air PaO2, mm Hg | 80.3 (11.1) | 81.0 (11.3) | 82.5 (10.1) |
| 6-min-walk distance, m | 370.5 (113.0) | 370.1 (115.2) | 378.2 (98.7) |
| Patient-reported outcomes scores, mean (SD) | |||
| UCSD Shortness of Breath Questionnaire* | 28.2 (19.0) | 27.6 (18.0) | 26.8 (15.6) |
| European Quality of Life score* | 0.81 (0.2) | 0.8 (0.2) | 0.8 (0.2) |
| SF-36 aggregate physical score* | 40.2 (9.2) | 40.3 (9.2) | 40.0 (8.9) |
| SF-36 aggregate mental score* | 53.7 (9.3) | 53.7 (9.5) | 53.8 (9.1) |
| Observed outcomes by 60 wk follow-up, n (%)† | |||
| All-cause death | 7 (4.0) | 4 (2.9) | 0 |
| FVC drop >10% | 43 (25.3) | 29 (21.9) | 20 (19.7) |
| Hospitalization | 33 (18.1) | 28 (19.6) | 13 (12.6) |
| Death, hospitalization, or FVC drop >10% | 65 (36.0) | 49 (34.7) | 28 (27.3) |
Definition of abbreviations: CAD = coronary artery disease; DlCO = diffusing capacity of the lung for carbon monoxide; GAP = gender-age-physiology; GERD = gastroesophageal reflux disease; HRCT = high-resolution computed tomography; SF-36 = 36-Item Short Form Survey; UCSD = University of California, San Diego.
*
UCSD Shortness of Breath Questionnaire scores range from 0 to 120, with higher scores indicating worse function; European Quality of Life scores range from 0 to 100 with higher scores indicating better quality of life; SF-36 scores range from 0 to 100, with higher scores indicating better function.
†
Kaplan-Meier estimators of failure probability at 60 weeks.