Table 2. Top ranking metabolites associated with T2D in lifestyle and groups* and their interaction with study group**.

	Study group	OR	Lower 95% CI	Higher 95% CI	P*	P**
Indolepropionic acid						0.19
	Lifestyle	0.46	0.28	0.76	0.002
	Control	0.62	0.40	0.95	0.029
PC(18:1/22:6)						0.02
	Lifestyle	0.34	0.19	0.59	2 × 10−4
	Control	0.69	0.45	1.05	0.086
LPC(19:0)						0.01
	Lifestyle	0.25	0.13	0.47	2 × 10−5
	Control	0.65	0.42	1.01	0.058
LPC(17:0)						0.19
	Lifestyle	0.33	0.19	0.58	1 × 10−4
	Control	0.50	0.32	0.80	0.004
LPC(20:1)						0.05
	Lifestyle	0.32	0.18	0.57	1 × 10−4
	Control	0.66	0.43	1.02	0.059
PC(22:6/18:2)						0.59
	Lifestyle	0.46	0.28	0.75	0.0021
	Control	0.50	0.32	0.80	0.0037
LPC(15:1)						0.09
	Lifestyle	0.41	0.24	0.69	7 × 10−4
	Control	0.67	0.44	1.03	0.066
PC(20:4/17:0)						0.38
	Lifestyle	0.41	0.24	0.70	0.001
	Control	0.61	0.39	0.95	0.029
PC(22:6/17:0)						0.95
	Lifestyle	0.57	0.36	0.91	0.019
	Control	0.51	0.32	0.82	0.005
PC(15:1/18:2)						0.87
	Lifestyle	0.58	0.37	0.92	0.020
	Control	0.56	0.36	0.88	0.012
LPE(16:0)						0.95
	Lifestyle	0.60	0.38	0.94	0.027
	Control	0.56	0.36	0.87	0.011
PC(18:2/15:0)						0.62
	Lifestyle	0.62	0.39	0.97	0.035
	Control	0.53	0.34	0.84	0.006
Tyrosine						0.01
	Lifestyle	1.38	0.89	2.12	0.15
	Control	3.48	1.95	6.22	3 × 10−5
Proline						0.001
	Lifestyle	0.99	0.65	1.50	0.96
	Control	3.24	1.84	5.69	4 × 10−5
Isoleucine						0.19
	Lifestyle	1.31	0.85	2.01	0.22
	Control	2.20	1.36	3.55	0.0013
Alanine						0.59
	Lifestyle	1.80	1.02	3.17	0.04
	Control	2.45	1.33	4.54	0.004
L-Phenylalanine						0.06
	Lifestyle	1.79	1.13	2.85	0.01
	Control	3.26	1.85	5.74	4 × 10−5

^*Refers to the association of the respective metabolite with T2D in the unadjusted logistic regression in each of the study group (Lifestyle; control).

^**Refers to the interaction of study group (lifestyle or control) vs. metabolite in the logistic regression testing the association of the respective metabolite with T2D adjusted for the study group.