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. 2017 Apr 11;7:46307. doi: 10.1038/srep46307

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(A) Flow cytometry was used to analyze the amount of ROS in paced HL-1 cells by transient transfection of Sesns siRNA and Sesns cDNA for 24 h. The transiently expressed Sesn1/2/3 siRNA increased the amount of ROS. The transiently expressed Sesn1/2/3 cDNA decreased the amount of ROS. (B) Quantification of relative ROS. n = 6, **P < 0.01 compared with the control group; ^ΔΔP < 0.01 compared with pacing group; ^##P < 0.01 compared with the pacing + siRNA C group; ^&&P < 0.01 compared with the pacing + pcDNA3.1 group.