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. 2017 Apr 11;7:46307. doi: 10.1038/srep46307

Figure 8. Sesns prevent AngII-induced proliferation of cardiac fibroblasts and collagen synthesis.

Figure 8

(A) CCK8 method was used to analyze the proliferation of cardiac fibroblasts induced by AngII or/and transient transfection of Sesn1/2 cDNA. (BD) mRNA levels of COLI, COLIII and FN1 in cardiac fibroblasts induced by AngII or/and transient transfection of Sesn1/2 cDNA were measured by RT-PCR. (EH) Protein levels of COLI, COLIII and FN1 in cardiac fibroblasts induced by AngII or/and transient transfection of Sesn1/2 cDNA were measured by western blot. Data are expressed as mean ± SEM (n = 6). **P < 0.01 compared with control group; #P < 0.05 compared with Ang II group.