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. Author manuscript; available in PMC: 2017 Apr 11.
Published in final edited form as: Curr Opin Struct Biol. 2016 Jan 12;36:40–47. doi: 10.1016/j.sbi.2015.12.006

Figure 1.

Figure 1

The primary path of mRNA degradation in eukaryotes. Shortening of the poly-A tail is followed by decapping by the Dcp1/Dcp2 complex and then either 5′→3′ decay by Xrn1 or 3′→5′ decay by the exosome complex.