Figure 2.

The dengue genome and proteome. The 5′ and 3′ untranslated regions and the arrangement of the genes encoding 3 structural and 7 nonstructural (NS) proteins are shown. The structures for capsid protein (C; PDB code: 1R6R), E-dimer (PDB code: 1UZG), premembrane and E (prM/E) proteins (PDB code: 3C6E), E-trimer (PDB code: 1OK8), and various images of the dengue virus virion reconstructed on the basis of cryo–electron microscopy (kindly provided by Dr Shee Mei Lok) are shown above the schematic of the genome, while the NS1 (PDB code: 4O6B), NS3 (PDB code: 2VBC), and NS5 (PDB code: 4V0R) structures are shown below. The figure was provided by Dr Dahai Luo.