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Effects of curcuminoids (CLE) and metformin (MET) on a) mean hot plate reaction time and b) hot plate reaction time difference of male mice respect to day 1. CON + HPT (Hot plate control). Values are mean ± SEM, n = 6. *Denotes statistically significant difference (Two way ANOVA followed by Bonferroni post hoc test) relative to CON + HPT group (*p < 0.05).
