Previous ICH or stroke of unknown origin at any time |
Transient ischemic attack in the preceding 6 months |
Menstruation |
Ischemic stroke in the preceding 6 months |
Oral anticoagulant therapy |
Acute Ischemic stroke within 4.5 h |
CNS damage or neoplasms or AV malformation |
Pregnancy or within 1 week postpartum |
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Recent major trauma/surgery/head injury (within the preceding 3 weeks) |
Refractory hypertension (systolic >180 mmHg and/or diastolic >100 mmHg) |
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GI bleeding within the past month |
Advanced liver disease |
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Known bleeding disorder (excluding menstration) |
Infective endocarditis |
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Aortic dissection |
Active peptic ulcer |
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Non-compressible punctures in the past 24 h (e.g. liver biopsy, lumbar puncture) |
Prolonged or traumatic resuscitation |
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