Table 16.

Randomized clinical Studies of Late Perfusion more than 24 h after onset of AMI.

Randomized Clinical Studies Of Late Reperfusion More Than 24H After The Onset Of AMI
Study	No of patients reperfused:+/−	Method of reperfusion	Time to reperfusion	Sustained patency reperfusion:+/−	Overall outcome
Topol et al, TAMI-G	71, 34/37	tPA+/−PTCA	12–40 h	60%/30% at 0 months	Negative (mortality, LV volume, LV systolic function at 0 months)
Dzavik V et al TOMIIS	44, 25/19	PTCA	5–42 days, mean 21 days	43%/19% at 4 months	Negative (clinical outcomes, LV size and CT at 4 months, positive in the subset LVEF at 4 months
Horie et al	83, 44/39	PTCA	>24 h	86%/13% at6 months	Positive (LV volume at 6months; death, recurrent MI, congestive heart failure at 56months)
Yousef et al	66,32/34	Stenting	3days- 5 weeks: mean-26days	81%/19% at 12 months	Greater LV dilation but improved exercise tolerance and QOL with reperfusion at 12 months
Steg et al DECOPI	212,109/103	Stenting	2–15days	83%/34% at 6months	Improved LVEF but no difference in clinical outcomes at 2 years
Hochman et al. OAT	2166,1082/1084	Stenting	3–28 days, median 8 days		Negative (event free survival at 4 years)
Dzavik V et al TOSCA-2	381, 150/136	Stenting	3–20 days; median 10 days	83%/25% at 1 year	Negative (LVEF at 4 years; trend towards less LV dilation in reperfusion)