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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Cancer Discov. 2016 Jul 15;6(9):986–1005. doi: 10.1158/2159-8290.CD-15-1297

Figure 7. Schematic illustration of the proposed deregulated IL-15 signaling pathway in T-cells.

Figure 7

(A) Epigenetic regulation of IL-15 transcription by Zeb1 in normal and malignant T-cells. Excessive methylation at the Zeb1 binding site promotes the aberrant production of IL-15 from CD4+ T cells. (B) Autocrine IL-15 production and consequent signaling in CD4+ T cells induces expression of chromatin modifiers HDAC1 and HDAC6. Upregulation of HDAC1 positively regulates expression of oncomir miR-21. Collectively, the deregulation of these enzymes by aberrant IL-15 signaling contributes to malignant transformation of a normal T-cell.