Table 1. Demographics and motor and nonmotor scale scores between fallers and non-fallers.
Median (range) or Number (%)
|
P-value a | ||
---|---|---|---|
Fallers (n=27) | Non-fallers (n=60) | ||
Demographics | |||
Age (years) | 70 (58–83) | 67.5 (44–86) | 0.44 |
Disease duration (years) | 10.8 (0.1–29.1) | 4.1 (0–22.8) | 0.005 |
Motor features
| |||
MDS-UPDRS part III | 36 (12–65) | 34 (9–70) | 0.24 |
Dyskinesia (% daytime) | 6 (0–75) | 0 (0–53) | 0.005 |
‘On’ without dyskinesia (%) | 76 (12–100) | 100 (7–100) | 0.006 |
‘Off’ time (%) | 12 (0–56) | 0 (0–54) | 0.04 |
Hoehn and Yahr stage | 3 (1–4) | 2 (2–5) | 0.018 |
Cognition
| |||
SCOPA-COG-total | 23 (9–32) | 26 (6–39) | 0.02 |
SCOPA-COG-memory | 8 (3–13) | 9 (1–18) | 0.07 |
SCOPA-COG-attention | 4 (2–4) | 4 (0–4) | 0.24 |
SCOPA-COG-executive | 8 (2–12) | 9 (2–12) | 0.003 |
SCOPA-COG-visuospatial | 4 (1–5) | 4 (0–5) | 0.25 |
Sleep
| |||
PSQI | 7 (2–19) | 5 (1–18) | 0.007 |
Epworth Sleepiness Score | 11 (1–20) | 5.5 (0–20) | 0.04 |
Presence of RBD | 13/27 (48%) | 11/60 (18%) | 0.004 |
Psychosis, apathy, fatigue, and depression
| |||
PPRS | 9 (6–14) | 6 (6–15) | <0.001 |
Lille Apathy Rating Scale | −25 (−35 to −3) | −26.5 (−35 to –2) | 0.30 |
Fatigue Severity Scale | 4.6 (1.8–7) | 4.0 (0–7) | 0.06 |
HADS anxiety | 7 (1–15) | 4.5 (0–16) | 0.06 |
HADS depression | 6 (2–12) | 4.5 (0–18) | 0.11 |
Autonomic function
| |||
SCOPA-AUT-total | 18 (11–36) | 10 (3–35) | <0.001 |
SCOPA-AUT-gastrointestinal | 4 (1–8) | 2 (0–10) | <0.004 |
SCOPA-AUT-urinary | 7 (1–15) | 4 (0–16) | 0.02 |
SCOPA-AUT-cardiovascular | 1 (0–6) | 0 (0–3) | 0.001 |
SCOPA-AUT-thermoregulatory | 2 (0–11) | 1 (0–10) | 0.07 |
SCOPA-AUT-pupillomotor | 1 (0–3) | 0 (0–3) | 0.001 |
SCOPA-AUT-sexual | 3 (0–6) | 2 (0–6) | 0.14 |
Abbreviations: HADS, Hospital Anxiety and Depression Scale; MDS-UPDRS, Movement Disorder Society-Unified Parkinson's Disease Rating Scale; PPRS, Parkinson Psychosis Rating Scale; PSQI, Pittsburgh Sleep Quality Index; RBD, REM sleep behavioral disorder; SCOPA-AUT, Scales For Outcomes in Parkinson's Disease Autonomic questionnaire; SCOPA-COG, Scales For Outcomes in Parkinson's Disease Cognition.
Mann–Whitney or χ 2-test.