Table S1.

Sensitivity analysis 1: patients without hypertension, congestive heart failure, or renal impairment prior to the index date

Thyroid disorders	Cases, n (%), N=33,191	Controls, n (%), N=45,363	OR crude (95% CI)	OR adj* (95% CI)
Hypothyroidism
No	32,604 (98.2)	44,597 (98.3)	1 (Reference)	1 (Reference)
Yes	587 (1.8)	766 (1.7)	1.29 (1.12–1.50)	1.12 (0.95–1.31)
Current diagnosis	67 (0.2)	69 (0.2)	1.40 (0.91–2.17)	1.13 (0.71–1.82)
Past diagnosis	520 (1.6)	697 (1.5)	1.28 (1.10–1.50)	1.12 (0.94–1.32)
Hyperthyroidism
No	33,028 (99.5)	45,116 (99.5)	1 (Reference)	1 (Reference)
Yes	163 (0.5)	247 (0.5)	1.25 (0.96–1.63)	0.73 (0.58–0.91)
Current diagnosis	8 (0.0)	18 (0.0)	0.65 (0.25–1.67)	0.70 (0.24–2.06)
Past diagnosis	155 (0.5)	229 (0.5)	1.32 (1.00–1.75)	1.35 (1.00–1.83)

Notes: Current diagnosis: last diagnosis within 180 days prior to (excluding) index date.

^*Adjusted for body mass index category, smoking status, alcohol consumption, and ischemic heart disease.

Abbreviations: adj, adjusted; CI, confidence interval; OR, odds ratio.