Table S2.
Sensitivity analysis 2: stratified by hypertension, congestive heart failure, and renal impairment
| Stratification variable | Cases, n (%), N=68,159 | Controls, n (%), N=68,159 | OR crude (95% CI) | OR adj* (95% CI) |
|---|---|---|---|---|
| Hypertension | ||||
| Hypothyroidism | ||||
| Without hypertension | ||||
| No | 39,564 (58.1) | 50,471 (74.1) | 1 (Reference) | 1 (Reference) |
| Yes | 1,216 (1.8) | 1,265 (1.9) | 1.46 (1.34–1.59) | 1.15 (1.05–1.26) |
| With hypertension | ||||
| No | 25,638 (37.6) | 15,480 (22.7) | 1 (Reference) | 1 (Reference) |
| Yes | 1,741 (2.6) | 943 (1.4) | 1.24 (1.14–1.35) | 1.10 (1.00–1.20) |
| Hyperthyroidism | ||||
| Without hypertension | ||||
| No | 40,484 (59.4) | 51,390 (75.4) | 1 (Reference) | 1 (Reference) |
| Yes | 296 (0.4) | 346 (0.5) | 1.25 (1.07–1.47) | 1.14 (0.96–1.36) |
| With hypertension | ||||
| No | 26,981 (39.6) | 16,192 (23.8) | 1 (Reference) | 1 (Reference) |
| Yes | 398 (0.6) | 231 (0.3) | 1.07 (0.91–1.27) | 1.01 (0.84–1.21) |
| Congestive heart failure | ||||
| Hypothyroidism | ||||
| Without congestive heart failure | ||||
| No | 60,992 (89.5) | 64,698 (94.9) | 1 (Reference) | 1 (Reference) |
| Yes | 2,500 (3.7) | 2,097 (3.1) | 1.32 (1.25–1.41) | 1.13 (1.05–1.21) |
| With congestive heart failure | ||||
| No | 4,210 (6.2) | 1,253 (1.8) | 1 (Reference) | 1 (Reference) |
| Yes | 457 (0.7) | 111 (0.2) | 1.19 (0.95–1.48) | 1.10 (0.87–1.40) |
| Hyperthyroidism | ||||
| Without congestive heart failure | ||||
| No | 62,948 (92.4) | 66,260 (97.2) | 1 (Reference) | 1 (Reference) |
| Yes | 544 (0.8) | 535 (0.8) | 1.11 (0.98–1.26) | 1.09 (0.95–1.25) |
| With congestive heart failure | ||||
| No | 4,517 (6.6) | 1,322 (1.9) | 1 (Reference) | 1 (Reference) |
| Yes | 150 (0.2) | 42 (0.1) | 0.98 (0.69–1.39) | 0.97 (0.66–1.41) |
| Renal impairment | ||||
| Hypothyroidism | ||||
| Without renal impairment | ||||
| No | 45,839 (67.3) | 52,886 (77.6) | 1 (Reference) | 1 (Reference) |
| Yes | 1,157 (1.7) | 1,097 (1.6) | 1.28 (1.18–1.40) | 1.14 (1.04–1.25) |
| With renal impairment | ||||
| No | 19,363 (28.4) | 13,065 (19.2) | 1 (Reference) | 1 (Reference) |
| Yes | 1,800 (2.6) | 1,111 (1.6) | 1.15 (1.06–1.25) | 1.11 (1.02–1.22) |
| Hyperthyroidism | ||||
| Without renal impairment | ||||
| No | 46,684 (68.5) | 53,635 (78.7) | 1 (Reference) | 1 (Reference) |
| Yes | 312 (0.5) | 348 (0.5) | 1.08 (0.92–1.26) | 1.13 (0.95–1.34) |
| With renal impairment | ||||
| No | 20,781 (30.5) | 13,947 (20.5) | 1 (Reference) | 1 (Reference) |
| Yes | 382 (0.6) | 229 (0.3) | 1.13 (0.95–1.35) | 1.02 (0.84–1.23) |
Notes:
*
Adjusted for body mass index category, smoking status, alcohol consumption, hypertension, and renal failure.
Abbreviations: adj, adjusted; CI, confidence interval; OR, odds ratio.