Table S3.
Sensitivity analysis 3: patients with treated gout compared with matched controls
| Thyroid disorders | Cases, n (%), N=45,466 | Controls, n (%), N=45,466 | OR crude (95% CI) | OR adj* (95% CI) |
|---|---|---|---|---|
| Hypothyroidism | ||||
| No | 43,478 (95.6) | 43,987 (96.8) | 1 (Reference) | 1 (Reference) |
| Yes | 1,988 (4.4) | 1,479 (3.3) | 1.39 (1.29–1.49) | 1.10 (1.02–1.20) |
| Current diagnosis | 165 (0.4) | 110 (0.2) | 1.54 (1.21–1.96) | 1.34 (1.01–1.77) |
| Past diagnosis | 1,823 (4.0) | 1,369 (3.0) | 1.37 (1.28–1.48) | 1.09 (1.00–1.18) |
| Hyperthyroidism | ||||
| No | 44,978 (98.9) | 45,063 (99.1) | 1 (Reference) | 1 (Reference) |
| Yes | 488 (1.1) | 403 (0.9) | 1.21 (1.06–1.39) | 1.03 (0.88–1.21) |
| Current diagnosis | 31 (0.1) | 24 (0.1) | 1.29 (0.76–2.20) | 0.92 (0.49–1.70) |
| Past diagnosis | 457 (1.0) | 379 (0.8) | 1.21 (1.05–1.39) | 1.04 (0.88–1.22) |
Notes: Current diagnosis: last diagnosis within 180 days prior to (excluding) index date.
*
Adjusted for body mass index category, smoking status, alcohol consumption, hypertension, renal failure, congestive heart failure, and ischemic heart disease.
Abbreviations: adj, adjusted; CI, confidence interval; OR, odds ratio.