Table S4.
Test for effect modification analysis 1: stratification by sex
| Stratification variable | Cases, n (%), N=68,159 | Controls, n (%), N=68,159 | OR crude (95% CI) | OR adj* (95% CI) |
|---|---|---|---|---|
| Male population | 53,736 (100) | 53,736 (100) | ||
| Hypothyroidism | ||||
| No | 52,547 (97.8) | 52,870 (98.4) | 1 (Reference) | 1 (Reference) |
| Yes | 1,189 (2.2) | 866 (1.6) | 1.39 (1.27–1.52) | 1.15 (1.04–1.28) |
| Current diagnosis | 138 (0.3) | 81 (0.2) | 1.72 (1.31–2.26) | 1.33 (0.98–1.81) |
| Past diagnosis | 1,051 (2.0) | 785 (1.5) | 1.35 (1.23–1.49) | 1.14 (1.02–1.26) |
| Hyperthyroidism | ||||
| No | 53,414 (99.4) | 53,502 (99.6) | 1 (Reference) | 1 (Reference) |
| Yes | 322 (0.6) | 234 (0.4) | 1.38 (1.16–1.63) | 1.16 (0.96–1.41) |
| Current diagnosis | 20 (0.0) | 15 (0.0) | 1.33 (0.68–2.60) | 1.13 (0.53–2.38) |
| Past diagnosis | 302 (0.6) | 219 (0.4) | 1.38 (1.16–1.64) | 1.17 (0.95–1.42) |
| Female population | 14,423 (100) | 14,423 (100) | ||
| Hypothyroidism | ||||
| No | 12,655 (87.7) | 13,081 (90.7) | 1 (Reference) | 1 (Reference) |
| Yes | 1,768 (12.3) | 1,342 (9.3) | 1.37 (1.27–1.48) | 1.07 (0.98–1.17) |
| Current diagnosis | 113 (0.8) | 83 (0.6) | 1.41 (1.06–1.87) | 1.28 (0.92–1.79) |
| Past diagnosis | 1,655 (11.5) | 1,259 (8.7) | 1.37 (1.27–1.48) | 1.06 (0.97–1.16) |
| Hyperthyroidism | ||||
| No | 14,051 (97.4) | 14,080 (97.6) | 1 (Reference) | 1 (Reference) |
| Yes | 372 (2.6) | 343 (2.4) | 1.09 (0.94–1.26) | 0.98 (0.82–1.17) |
| Current diagnosis | 20 (0.1) | 18 (0.1) | 1.11 (0.59–2.11) | 0.89 (0.42–1.89) |
| Past diagnosis | 352 (2.4) | 325 (2.3) | 1.09 (0.93–1.27) | 0.98 (0.82–1.18) |
Notes: Current diagnosis: last diagnosis within 180 days prior to (excluding) index date.
*
Adjusted for body mass index category, smoking status, alcohol consumption, hypertension, renal failure, congestive heart failure, and ischemic heart disease.
Abbreviations: adj, adjusted; CI, confidence interval; OR, odds ratio.