Table 5.
Thyroid diseases of patients with gout and matched control patients stratified by GFR
| Glomerular filtration rate | Cases, n (%), N=68,159 | Controls, n (%), N=68,159 | OR crude (95% CI) | OR adj* (95% CI) |
|---|---|---|---|---|
| Value of last eGFR prior to the index date | ||||
| Overall population | ||||
| No value | 41,340 (60.7) | 48,440 (71.1) | 0.38 (0.36–0.39) | 0.66 (0.63–0.69) |
| <30 mL/min | 1,119 (1.6) | 194 (0.3) | 10.99 (9.18–13.16) | 7.76 (6.41–9.40) |
| 30–60 mL/min | 5,306 (7.8) | 2,972 (4.4) | 2.90 (2.69–3.12) | 2.43 (2.24–2.63) |
| 60–90 mL/min | 20,394 (29.9) | 16,553 (24.3) | 1 (Reference) | 1 (Reference) |
| Hypothyroidism | ||||
| Hypothyroidism, no value | 946 (1.4) | 850 (1.3) | 1.39 (1.26 – 1.53) | 1.25 (1.09–1.35) |
| No hypothyroidism, no value | 40,394 (59.3) | 47,590 (69.8) | 1 (Reference) | 1 (Reference) |
| Hypothyroidism, <30 mL/min | 184 (0.3) | 34 (0.1) | 0.85 (0.55–1.31) | 0.79 (0.50–1.24) |
| No hypothyroidism, <30 mL/min | 935 (1.4) | 160 (0.2) | 1 (Reference) | 1 (Reference) |
| Hypothyroidism, 30–59 mL/min | 735 (1.1) | 384 (0.6) | 1.14 (0.99–1.32) | 1.03 (0.88–1.21) |
| No hypothyroidism, 30–59 mL/min | 4,571 (6.7) | 2,588 (3.8) | 1 (Reference) | 1 (Reference) |
| Hypothyroidism, 60–90 mL/min | 1,092 (1.6) | 940 (1.4) | 1.07 (0.97–1.18) | 1.01 (0.90–1.12) |
| No hypothyroidism, 60–90 mL/min | 19,302 (28.3) | 15,613 (22.9) | 1 (Reference) | 1 (Reference) |
| Hyperthyroidism | ||||
| Hyperthyroidism, no value | 946 (0.4) | 283 (0.4) | 1.17 (0.98–1.39) | 1.25 (1.03–1.52) |
| No hyperthyroidism, no value | 40,394 (60.3) | 48,157 (70.6) | 1 (Reference) | 1 (Reference) |
| Hyperthyroidism, <30 mL/min | 184 (0.1) | 5 (0.01) | 1.11 (0.41–3.01) | 1.02 (0.36–2.93) |
| No hyperthyroidism, <30 mL/min | 1,087 (1.6) | 189 (0.3) | 1 (Reference) | 1 (Reference) |
| Hyperthyroidism, 30–59 mL/min | 144 (0.2) | 82 (0.1) | 0.98 (0.72–1.32) | 0.88 (0.63 – 1.23) |
| No hyperthyroidism, 30–59 mL/min | 5,162 (7.6) | 2,890 (4.2) | 1 (Reference) | 1 (Reference) |
| Hyperthyroidism, 60–90 mL/min | 259 (0.4) | 207 (0.3) | 1.09 (0.90–1.33) | 0.94 (0.75–1.17) |
| No hyperthyroidism, 60–90 mL/min | 20,135 (29.5) | 16,346 (24.0) | 1 (Reference) | 1 (Reference) |
Notes: The reference is in each category the same kidney function category without the respective thyroid disease, eg, hypothyroidism <30 mL/min compared to no hypothyroidism <30 mL/min.
*
Adjusted for body mass index category, smoking status, alcohol consumption, hypertension, renal failure, congestive heart failure, and ischemic heart disease.
Abbreviations: adj, adjusted; CI, confidence interval; eGFR, estimated glomerular filtration rate; OR, odds ratio.