Figure 2.

Treatment of T. cruzi-infected mice (inoculum of 10⁴ per animal using BT from Y strain) with DB1957, DB1959, and DB1890B.

Notes: The activities of 25 mg/kg of compounds and 100 mg/kg of the reference drug Bz (by per oral) were also evaluated using similar therapeutic schemes at the 5–9 dpi. Parasitemia curve (A) and survival rates (B) are shown. All assays were run at least two times. Statistical analysis: all groups with P≤0.05.

Abbreviations: T. cruzi, Trypanosoma cruzi; BT, bloodstream trypomastigote; Bz, benznidazole.