Figure 1.
Treatment scheme (A) and experimental setup (B) for in vivo experiments.
Notes: (A) Applied treatment scheme for the performed in vivo experiments. (B) Magnetic heating was induced by exposing the intratumorally applied nanoparticles (orange spots) to an AMF (H =23.9 kA/m, f =410 kHz). An IR was placed vertically above the tumor/coil for acquiring tumor surface temperatures (heat maps). Body temperature was controlled rectally via fiber optic temperature sensors. Anesthetized mice were placed in a water-perfused heat shell to prevent hypothermia during treatment. Copyright ©2017. Dove Medical Press. Adapted from Stapf M, Pömpner N, Kettering M, Hilger I. Magnetic thermoablation stimuli alter BCL2 and FGF-R1 but not HSP70 expression profiles in BT474 breast tumors. Int J Nanomedicine. 2015;10(10):1931–1939.17
Abbreviations: AMF, alternating magnetic field; CT, computerized tomography; IR, infrared thermography camera.